HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-(trifluoromethyl)nicotinic acid → 2-(3-(4-Fluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-(trifluoromethyl)nicotinic acid | HCID 12140227 | — |
| Reactant | 3-(4-Fluorophenoxy)azetidine | HCID 21428730 | — |
| Product | 2-(3-(4-Fluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid | HCID 67958387 | — |
Reaction Steps
The title compound (D122) (180 mg) was prepared according to the experimental procedure described in Description 121 starting from 3-(4-fluorophenoxy)azetidine) (D49) (177.89 mg, 1.064 mmol) and 2-chloro-5-(trifluoromethyl)nicotinic acid (200 mg, 0.886 mmol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-a1960416f904479985ec4d3e722ad8c2 |
| Source note | uspto-grants-2014_09 |