Hydrochloric Acid → HCID 11633706, compound

Participants

Reaction Conditions

Reaction Steps

Methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate trifluoroacetate (286 mg, 0.649 mmol) in methanol (7.0 mL) was treated with triethylamine (362 μL, 2.60 mmol) and cooled to 0° C. Benzyl chloroformate (116 μL, 0.812 mmol) was added and the solution stirred for 2 h. 2 M lithium hydroxide in water (0.81 mL) was added and the solution stirred for an additional 1 h. The reaction soluiton was acidified with 1 N HCl and extracted with ethyl acetate. The crude product was used in the next step without purification. MF=C21H22N2O7S; LCMS found for C21H23N2O7S (M+H)+: m/z=447.

Provenance & Evidence