Trifluoroacetic acid → HCID 86602084, compound

Participants

Reaction Steps

A solution of ethyl [((1S)-1-(1h-benzimidazol-2-yl)-2-[4-(2-tert-butyl-1,1-dioxido-3-oxoisothiazolidin-5-yl)phenyl]ethylamino)carbonyl]aminoacetate (4 mg, 7.20 μmol) and trifluoroacetic acid (1.50 mL) was heated at 120° C. for 5 min in the microwave. The reaction concentrated in vacuo and purified by preparative LCMS to yield the desired product (1.5 mg, 34%). 1H NMR (400 MHz, CD3OD): δ 7.7 (m, 2H), 7.6 (m, 2H), 7.5 (m, 2H), 7.3 (m, 2H), 5.3 (m, 1H), 5.2 (m, 1H), 4.2 (m, 2H), 3.8 (m, 2H), 3.5–3.3 (m, 4H), 1.2 (t, 3H); MF=C25H26F3N5O8S; LCMS found for C23H26N5O6S (M+H)+: m/z=500.

Provenance & Evidence