HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-[4-(4-Fluorophenyl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl triflate | HCID 9526 | — |
| Reactant | 4-(4-Fluorophenyl)-1-[(2-methyl-1H-imidazol-1-yl)sulfonyl]-1,2,3,6-tetrahydropyridine | HCID 21878685 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[4-(4-Fluorophenyl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate | HCID 21878610 | 42.4% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A solution of 4-(4-fluorophenyl)-1-[(2-methyl-1h-imidazol-1-yl)sulfonyl]-1,2,3,6-tetrahydropyridine (125 mg, 389 μmol), triethylamine (54 μL, 390 μmol) and methylene chloride (5.4 mL) was stirred at 0° C. and slowly added methyl trifluoromethanesulfonate (43 μL, 390 μmol). The reaction mixture was stirred at 0° C. for 1 h. The resulting precipitate was filtered to yield the desired product (80 mg, 42%). MF=C17H19F4N3O5S2; LCMS found for C16H20FN3O2S(M+H)+: m/z=336.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07141596B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-0246250a7efe4ceeac5964c1ca429ffb |
| Source note | uspto-grants-2006_11 |