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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 72474Generated: October 25, 2026

4-Fluoro-3-(trifluoromethyl)phenol → 2-(3-(4-Fluoro-3-(trifluoromethyl)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid

https://huagongshe.com/reaction/72474

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-3-(trifluoromethyl)phenolHCID 601854—
ReactantMethyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinateHCID 86697871—
Product2-(3-(4-Fluoro-3-(trifluoromethyl)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acidHCID 8669787598.7%

Reaction Steps

The title compound (D125) (108 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 4-Fluoro-3-(trifluoromethyl)phenol (60.98 mg, 0.338 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08828987B2
Source datasetuspto-grants-2014_09
ORD IDord-79e437b0e96046e6aff8e2a56f024a1e
Source noteuspto-grants-2014_09