HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluorophenol → 2-(3-(2,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluorophenol | HCID 123051 | — |
| Reactant | Methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate | HCID 86697871 | — |
| Product | 2-(3-(2,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid | HCID 67958434 | 98.4% |
Reaction Steps
The title compound (D127) (95 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 2,4-Difluorophenol (0.032 ml, 0.338 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7632ee7e99274dd39d4f902fd9eeec21 |
| Source note | uspto-grants-2014_09 |