HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluorophenol → 2-(3-(3,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluorophenol | HCID 75927 | — |
| Reactant | Methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate | HCID 86697871 | — |
| Product | 2-(3-(3,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid | HCID 67958244 | 103.6% |
Reaction Steps
The title compound (D128) (100 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 3,4-Difluorophenol (44.06 mg, 0.338 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-fad1ebcbe7ba41e297cb888617862a54 |
| Source note | uspto-grants-2014_09 |