Water → HCID 19710973, compound

Participants

Reaction Steps

A stirred solution of 1-(3-trifluoromethoxyphenyl)-3-(3-chloro-2,2-dimethylpropanoyl)amino-2-pyrrolidinone (0.31 g) in THF (5 ml) was treated with a 60% dispersion of sodium hydroxide in oil (0.036 g). Once the effervescence had ceased, the yellow mixture was stirred for 5 min then poured into water. The mixture was extracted with dichloromethane (x2), the combined extracts were washed with brine and dried (MgSO4). Evaporation of the solvent under reduced pressure left an oil, which was purified by chromatography on silica-gel, eluting with ethyl acetate/hexane mixtures, to give the title compound as a pale tan crystalline solid (0.20 g).

Provenance & Evidence