HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Azido-3-[3-(trifluoromethoxy)phenyl]-4-thiazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 19710965 | HCID 19710965 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Azido-3-[3-(trifluoromethoxy)phenyl]-4-thiazolidinone | HCID 19710968 | 70.4% |
Reaction Steps
Sodium azide (2.78 g) was added to a solution of 5-chloro-3-(3-trifluoromethoxyphenyl)thiazolidin-4-one (7.50 g) in DMF (50 ml). After 2 hours the mixture was poured into water, extracted with ethyl acetate (x3), dried (MgSO4) and concentrated in vacuo to give the sub-title compound (5.40 g), which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05705456 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-71eaaef2a35c4368b7ac6d281bce8344 |
| Source note | uspto-grants-1998_01 |