1,1',1''-(Chlorosilylidyne)tris(benzene) → HCID 178420877, compound

Participants

Reaction Steps

14.3 g of 6-chloro-9-β-D-ribofuranosyl-9H-purine and 15 g of triphenylchlorosilane were dissolved in 500 ml of pyridine and stirred for one hour at room temperature. Pyridine was distilled away and the residue was dissolved in benzene. The benzene layer was washed with 1N HCl and brine, and then dried over sodium sulfate anhydride. The solvent was distilled off and the residue was recrystallized from a mixture of hexane and ethyl acetate to give 21.5 g of 6-chloro-9-15-O-triphenylsilyl-β-D-ribofuranosyl)-9H-purine.

Provenance & Evidence