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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 72481Generated: October 25, 2026

3-Fluorophenol → 5-Fluoro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acid

https://huagongshe.com/reaction/72481

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-FluorophenolHCID 9743—
ReactantMethyl 5-fluoro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinateHCID 86697878—
Product5-Fluoro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acidHCID 67958637119.5%

Reaction Steps

The title compound (D132) (108 mg) was prepared according to the experimental procedure described in Description 115 starting from methyl 5-fluoro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D71) (90 mg, 0.295 mmol) and 3-Fluorophenol (0.029 ml, 0.295 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08828987B2
Source datasetuspto-grants-2014_09
ORD IDord-c613aafd2f95412e82b2c5be69c870a5
Source noteuspto-grants-2014_09