Water → HCID 19711091, compound

Participants

Reaction Conditions

Reaction Steps

5 ml of triethylamine and then, dropwise with stirring, 4 ml of acetyl chloride are added to a solution of 12 g of 3-[2-(N,N-diethylamino)ethoxycarbonyl]-5-(1,2,3,4-tetrahydro-6-quinolyl)-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one [obtainable in analogy to Example 1 by reacting 5-(1,2,3,4-tetrahydro-6-quinolyl)-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one with 2-(N,N-diethylamino)ethyl chloroformate] in 100 ml of dichloromethane. The mixture is subsequently stirred at 20° C. for one hour and decomposed with water and the mixture is worked up in the conventional manner to give 3-[2-(N,N-diethylamino)ethoxycarbonyl]-5-(1-acetyl-1,2,3,4-tetrahydro-6-quinolyl)-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one.

Provenance & Evidence