Dimethylformamide → N-(3-chloro-phenyl)-4-(2-dimethylamino-4-pyridyl)-2-pyrimidineamine

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	1,3-Propanediol	HCID 10442	—
Reactant	N-(3-chlorophenyl)-4-(2-chloropyridin-4-yl)pyrimidin-2-amine	HCID 9905031	—
Product	N-(3-chloro-phenyl)-4-(2-dimethylamino-4-pyridyl)-2-pyrimidineamine	HCID 21948226	—

Reaction Steps

300 mg (0.95 mmol) of N-(3-chloro-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine (see Example 1), 5.3 ml of 1,3-propanediol and 3.0 ml of dimethylformamide are stirred for 43 hours at 105°. After concentration and repeated chromatography (methylene chloride:methanol=98:2) N-(3-chloro-phenyl)-4-(2-dimethylamino-4-pyridyl)-2-pyrimidineamine is obtained; m.p. 176°-178°, FAB-MS: 326 (M+ +H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05705502
Source dataset	uspto-grants-1998_01
ORD ID	ord-c3482e11c2e84dc49fa14c44b98d45d5
Source note	uspto-grants-1998_01