HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → N-[3-ethoxycarbonyl-phenyl]-4-(2-chloro4-pyridyl)-2-pyrimidineamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Dimethylamino-1-(2-chloro4-pyridyl)-2-propen-1-one | HCID 54435039 | — |
| Reactant | HCID 178468910 | HCID 178468910 | — |
| Solvent | Isobutanol | HCID 6560 | — |
| Product | N-[3-ethoxycarbonyl-phenyl]-4-(2-chloro4-pyridyl)-2-pyrimidineamine | HCID 19689549 | — |
Reaction Steps
14.5 g (53.7 mmol) of 3-ethoxycarbonyl-phenyl-guanidine nitrate, 11.3 g (53.7 mmol) of 3-dimethylamino-1-(2-chloro4-pyridyl)-2-propen-1-one and 2.4 g (60 mmol) of sodium hydroxide are stirred in 150 ml of isobutanol for 14 hours at 110°. After cooling, washing twice with 100 ml of ethanol each time and crystallising (tetra-hydrofuran/ethanol), N-[3-ethoxycarbonyl-phenyl]-4-(2-chloro4-pyridyl)-2-pyrimidineamine is obtained; m.p. 149°-150°, FAB-MS: 355 (M+ +H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05705502 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-350217ff633a4adb92efcce968455ad8 |
| Source note | uspto-grants-1998_01 |