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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 72483Generated: October 25, 2026

3-(Trifluoromethoxy)phenol → 5-Fluoro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinic acid

https://huagongshe.com/reaction/72483

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethoxy)phenolHCID 2733261—
ReactantMethyl 5-fluoro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinateHCID 86697878—
Product5-Fluoro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinic acidHCID 6795847022.1%

Reaction Steps

The title compound (D134) (27 mg) was prepared according to the experimental procedure described in Description 133 starting from Methyl 5-fluoro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D71) (100 mg, 0.328 mmol) and 3-(trifluoromethoxy)phenol (0.042 ml, 0.328 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08828987B2
Source datasetuspto-grants-2014_09
ORD IDord-672015aa4a3f4268a48e9a966c42849c
Source noteuspto-grants-2014_09