HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-Ethoxycarbonyl-3-(4-nitrophenyl)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (4-Nitrophenyl)acetate | HCID 6931101 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3-Ethoxycarbonyl-3-(4-nitrophenyl)propionic acid | HCID 11807640 | — |
Reaction Steps
Following a similar procedure to that described in reference example 7b, but starting fromethyl 4-nitrophenylacetate instead of ethyl diphenylacetate, and hydrolizing then the tert-butyl ester using p-toluenesulfonic acid in benzene at reflux instead of using trifluoroacetic acid, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05705504 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-c2c552ccf12b44bfa6feed885d81df99 |
| Source note | uspto-grants-1998_01 |