Sodium Cyanide → HCID 12241882, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-chloro-2-methyl-2-phenylpropane (150 g, 0.889 mol) and NaCN (54.46 g) in DMSO (250 mL) was heated at 100° C. for 3 weeks. The solution was concentrated to half the initial volume, H2O (400 mL) was added and it was extracted with Et2O (3×). The combined organic extracts were dried and concentrated to a crude product (115.1 g), which was directly used in the next step as obtained.

Provenance & Evidence