4-Chlorobenzoyl chloride → HCID 23161670, compound

Participants

Reaction Steps

Compound 26, an intermediate in the preparation of compound 1, can be prepared in several steps beginning with 3,5-dichlorobenzyl alcohol. The alcohol is protected as a t-butyldimethylsilyl ether, then treated with n-butyllithium followed by 4-chlorobenzoyl chloride to produce 4-(t-butyldimethylsilyloxymethyl-2,4',6-trichlorobenzophenone. Removal of the silyl protecting group provides compound 26.

Provenance & Evidence