Ethylamine → N-(2,6-Dichloro-3-pyridinyl)-2-ethylamino-3-pyridinecarboxamide

Participants

Reaction Conditions

Reaction Steps

A mixture of N-(2,6-dichloro-3-pyridinyl)-2-chloro-3-pyridinecarboxamide (12.0 g, 39.8 mmol), ethylamine (3.6 g, 80.7 mmol), and 30 mL of xylenes in a sealed vessel was heated at 165° C. for 6 hours. The reaction mixture was cooled to room temperature and extracted with ethyl acetate to give 7.4 g of the title compound, suitable for use in the next reaction.

Provenance & Evidence