Pyridine → HCID 470762, compound

Participants

Reaction Steps

To a solution of 8-[2-(4-aminophenyl)ethyl]-2-chloro-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (16 mg, 0.04 mmol) and 6 μL of pyridine in dichloromethane at 0° C. was added 5 μL of methanesulfonyl chloride. The reaction mixture was allowed to stir at room temperature overnight. The orange reaction mixture was then concentrated to dryness and the product was purified by flash chromatography, eluting with methanol/dichloromethane, and recrystallization from ethanol/hexanes to give 6 mg of the title compound, m.p. 199°-204° C.

Provenance & Evidence