Dichloromethane → HCID 15956321, compound

Participants

Reaction Steps

2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(cis-2-phenylethen-1-yl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (prepared by procedures analogous to those described in Example 43) (51 mg, 0.13 mmol) was dissolved in 3 mL of dichloromethane and treated with m-chloroperbenzoic acid (50%, 45 mg, 0.13 mmol) at room temperature. Solid Ca(OH)2 was added, and the reaction mixture was filtered and concentrated. Purification by flash chromatography (elution with ethyl acetate-hexanes) and recrystallization (diethyl ether-hexanes) afforded the title compound (11 mg, 21%), m.p. 105°-107° C.

Provenance & Evidence