3-Bromopyridine → HCID 10546110, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing 5,11-dihydro-11-ethyl-8-ethynyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.19 g, 0.68 mmol), 3-bromopyridine (0.07 mL, 0.73 mmol), tetrakis(triphenylphosphine)palladium(0), triethylamine (2 mL), and 1 crystal of BHT was heated at 85° C. in a sealed tube for 7 hours. Solvent was removed, and the residue was purified by flash chromatography, eluting with ethyl acetate/hexanes, and recrystallization from ethanol/hexanes to give 0.16 g of the title compound as yellow crystals, m.p. 178°-180° C.

Provenance & Evidence