Methyl 4-iodobenzoate → HCID 15956327, compound

Participants

Reaction Steps

5,11-dihydro-11-ethyl-8-ethynyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.1 g, 0.36 mmol) was coupled with methyl 4-iodobenzoate (0.1 g, 0.38 mmol) by a procedure analogous to that described in Example 51b to give 79 mg of an olefinic coupled product, 5,11-Dihydro-11-ethyl-5-methyl-8-[2-(4-methoxycarbonylphenyl)ethen-1-yl]-(-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one. Hydrogenation as described in Example 56 afforded 22 mg of the title compound, m.p. 172°-173° C. (ethyl acetate/hexanes).

Provenance & Evidence