4-Bromopyridine-2-carboxylic acid → HCID 470750, compound

Participants

Reaction Steps

By a procedure analogous to that described in Example 51b, 2-chloro-5,11-dihydro-11-ethyl-8-ethynyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.83 g, 2.64 mmol) was coupled with 4-bromopicolinic acid (prepared by potassium permanganate oxidation of 4-bromo-2-picoline) (0.53 g, 2.62 mmol). The product was hydrogenated according to the procedure described in Example 3b to provide 0.4 g of the title compound as a mixture containing the corresponding des-chloro analog.

Provenance & Evidence