Acetylene → HCID 15956330, compound

Participants

Reaction Steps

By a procedure analogous to that described in Example 51b, 60 mg (0.20 mmol) of 5,11-dihydro-11-ethyl-8-ethynyl-2-fluoro-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diaepin-6-one [prepared from 8-bromo-5,11-dihydro-11-ethyl-2-fluoro-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (see Example 38) by a route analogous to that described in Example 51a] was coupled with 3-bromoquinoline. Hydrogenation of the resultant acetylene was accomplished as described in Example 3b to provide 6 mg of the title compound, m.p. 154°-156° C. (petroleum ether).

Provenance & Evidence