HRID72497

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66824369

未命名化合物

结构：O=C(O)c1cc(Cl)cnc1N1CC(Oc2cccc(OC(F)(F)F)c2)C1

HCID67958627

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CC(Oc4cccc(OC(F)(F)F)c4)C3)CC2)cc1

HCID67958054

未命名化合物

收率 75.7%

PROCEDURE

实验过程

The title compound (D153) (120 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-chloro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinic acid (D107) (110 mg, 0.282 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (64.43 mg, 0.282 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9e2cf632f79244b7a49899652a40fbc3
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08828987B2
来源说明: uspto-grants-2014_09

反应 SMILES

[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:11]2[CH2:14][CH:13]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]([F:26])([F:25])[F:24])[CH:17]=3)[CH2:12]2)=[C:6]([CH:10]=1)[C:7](O)=[O:8].Cl.[NH2:28][C:29]1([C:32]2[CH:41]=[CH:40][C:35]([C:36]([O:38][CH3:39])=[O:37])=[CH:34][CH:33]=2)[CH2:31][CH2:30]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:11]2[CH2:12][CH:13]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]([F:24])([F:26])[F:25])[CH:17]=3)[CH2:14]2)=[C:6]([CH:10]=1)[C:7]([NH:28][C:29]1([C:32]2[CH:41]=[CH:40][C:35]([C:36]([O:38][CH3:39])=[O:37])=[CH:34][CH:33]=2)[CH2:31][CH2:30]1)=[O:8]