HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenol → 2-chloro-5,11-dihydro-11-ethyl-8-(3-fluorophenyl)methyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenol | HCID 9743 | — |
| Reactant | 2-chloro-8-chloromethyl-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 10830738 | — |
| Product | 2-chloro-5,11-dihydro-11-ethyl-8-(3-fluorophenyl)methyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 15956337 | 70% |
Reaction Steps
Using a procedure analogous to that described in Example 98, the title compound, m.p. 104°-105° C., was prepared from 2-chloro-8-chloromethyl-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and 3-fluorophenol. The yield was 70% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05705499 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-0e4336f3066c43919b96d074bbcdc579 |
| Source note | uspto-grants-1998_01 |