Methyl Salicylate → HCID 470682, compound

HRID 724982Notes

Reaction equation

HRID 724982 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH3:22])[C:7](=[O:21])[C:8]3[CH:18]=[C:17]([CH2:19]Cl)[CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1.[C:23]([O:32][CH3:33])(=[O:31])[C:24]1[C:25](=[CH:27][CH:28]=[CH:29][CH:30]=1)[OH:26]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH3:22])[C:7](=[O:21])[C:8]3[CH:18]=[C:17]([CH2:19][O:26][C:25]4[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=4[C:23]([O:32][CH3:33])=[O:31])[CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1

Participants

3

Reactant 2

HCID 4133Methyl SalicylateHCID 108307382-chloro-8-chloromethyl-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Product 1

HCID 470682HCID 470682, compoundYield 57%

Procedure

Using a procedure analogous to that described in Example 98, the title compound, m.p. 155°-156° C., was prepared from 2-chloro-8-chloromethyl-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and methyl salicylate. The yield was 57% of theory.

Sources & evidence

ORD record
ord-6f42a40654de4e2c86ccd095787c452d
Source dataset
uspto-grants-1998_01
Patent number
US05705499

Reaction notes

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