HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(aminomethyl)benzoate hydrochloride → Methyl 4-((5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)methyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(aminomethyl)benzoate hydrochloride | HCID 2729253 | — |
| Reactant | 5-Chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acid | HCID 67958861 | — |
| Product | Methyl 4-((5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)methyl)benzoate | HCID 67958190 | 76% |
Reaction Steps
The title compound (D157) (55 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acid (D103) (50 mg, 0.154 mmol) and Methyl 4-(aminomethyl)benzoate hydrochloride (31.24 mg, 0.154 mmol, available at Aldrich#328383).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-6fec37722d114c3c89411e26257d38c3 |
| Source note | uspto-grants-2014_09 |