反应详情

A solution of 3-benzyloxybenzyl alcohol (2.04 g) in methylene chloride (20 mL) with TMS Bromide (2.5 eq. 3.14 mL) was heated at reflux for 6 hr. After cooling, the reaction was concentrated and then reconcentrated 2× from methylene chloride. The residue was chromatographed on silica gel with 5% methylene chloride in hexane to afford 3-benzyloxybenzyl bromide (1.26 g) as an oil.

1. temperatureat reflux for 6 hr
2. temperatureAfter cooling
3. concentrationthe reaction was concentrated
4. customThe residue was chromatographed on silica gel with 5% methylene chloride in hexane