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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 72504Generated: October 26, 2026

HCID 67958246, compound → Methyl 6-(1-(5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)cyclopropyl)nicotinate

https://huagongshe.com/reaction/72504

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 67958246HCID 67958246—
Reactant5-Chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acidHCID 67958861—
ProductMethyl 6-(1-(5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)cyclopropyl)nicotinateHCID 6795812224.2%

Reaction Steps

The title compound (D159) (22.4 mg) was prepared according to the experimental procedure described in Description 146 starting from 5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acid (D103) (60 mg, 0.186 mmol) and methyl 6-(1-aminocyclopropyl)nicotinate hydrochloride (D12) (28.5 mg, 0.186 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08828987B2
Source datasetuspto-grants-2014_09
ORD IDord-8f333c2c9bc14c3ca878d432ab868fae
Source noteuspto-grants-2014_09