4-Phenylpiperidin-4-ol → HCID 21839953, compound

Participants

Reaction Steps

3-(3,4-dichlorophenyl)-3-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.75 g) was coupled to 4-hydroxy-4-phenyl-piperidine (0.34 g) as described in Example 1. After chromatography, using dichloromethane:methanol (20:1) as eluent, the free amine was converted to the hydrochloride salt, to give the title compound as a white solid (0.4 g); mp 190° C.(dec); MS: m/z=495(M+1); NMR (CDCl3): 2.02 (broad,4), 2.70 (broad,4), 4.92 (broad,1), 6.95-7.73 (m,12). Analysis for C28H28Cl2N2O2.HCl.0.5 H2O: Calculated: C, 62.17; H, 5.59; N, 5.18; Found: C, 62.01; H, 5.54; N, 4.98.

Provenance & Evidence