2-(Piperidin-1-yl)phenol → 2-(Piperidin-4-yl)phenol

HRID 725072Notes

Reaction equation

HRID 725072 reaction equation
OC1C=CC=CC=1N1CCCCC1.C(OC([N:24]1[CH2:29][CH2:28][CH:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[O:36]CC2C=CC=CC=2)[CH2:26][CH2:25]1)=O)C1C=CC=CC=1>>[OH:36][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=1[CH:27]1[CH2:26][CH2:25][NH:24][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 32622502-(Piperidin-1-yl)phenolHCID 226224391-Benzyloxycarbonyl-4-(2-benzyloxyphenyl)piperidine

Product 1

HCID 107024522-(Piperidin-4-yl)phenol

Procedure

4-(2-Hydroxyphenyl piperidine. 1-Benzyloxycarbonyl-4-(2-benzyloxyphenyl)piperidine was subjected to a procedure similar to that described in Example 10 sub-part c. to give 4-(2-hydroxyphenyl)piperidine as a brown solid (0.36 g); NMR (CDCl3): 1.7-1.9 (m,4), 2.77-2.86 (m,2), 2.99-3.04 (m,1), 3.23 (d,2, J=12), 4.17 (s,2), 6.72 (d,1, J=8), 6.84 (t,1, J=7), 7.05 (m,1); MS: m/z=178(M+1). This material was used in the next step without further purification.

Sources & evidence

ORD record
ord-bfe3f1826178461783ed5595fe5c171e
Source dataset
uspto-grants-1998_01
Patent number
US05705505

Reaction notes

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