4-Phenylpiperidin-4-ol → HCID 19711216, compound

Participants

Reaction Steps

3-(3,4-Dichlorophenyl)-3-(4-methoxy-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.95 g) was coupled to 4-hydroxy-4-phenylpiperidine (0.44 g) by a method similar to that described in Example 8. The reaction product was purified by chromatography and converted to the corresponding hydrochloride salt as described in the Example 8 to afford the title compound (0.838 g); mp 163°-185° C.; MS: m/z=539(M+1); NMR(CD3SOCD3): 1.78 (m,2), 2.10 (m,1), 2.98-3.22 (two peaks,3), 3.77 (s,3), 4.77 (m,1), 5.45 (m,1) 6.69-7.58 (m,11). Analysis for C30H32Cl2N3O2.1.0.HCl.1.0H2O: Calculated: C, 60.66; H, 5.94, N, 4.71; Found: C, 60.67; H, 5.94; N, 4.71.

Provenance & Evidence