4-Phenylpiperidin-4-ol → HCID 21839807, compound

Participants

Reaction Steps

3-(3,4-Dichlorophenyl)-3-(6-fluoro-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (2.05 g) was coupled to 4-hydroxy-4-phenylpiperidine (1.0 g) by a method similar to that described in Example 8. The reaction product was purified by chromatography and converted to the corresponding hydrochloride salt as described in the Example 8 to afford the title compound (2.05 g); mp 160-205° C.; MS: m/z=527(M+1); NMR(CD3 SOCD3): 1.78 (m,2), 2.17 (m, 1), 3.12 (s,3), 4.89 (m,1), 6.88 (d,1, J=8.3), 7.10-7.59 (m,9), 7.84 (d,1, J=8.7). Analysis for C29H29Cl2N2O2F.1.0 HCl.1.0 H2O: Calculated: C, 59.85; H, 5.54, N, 4.81; Found: C, 60.15; H, 5.39; N, 4.81.

Provenance & Evidence