1-(Piperidin-4-yl)-1,3-diazinan-2-one → HCID 21839776, compound

Participants

Reaction Steps

3-(3,4-Dichlorophenyl)-3-(6-isopropoxy-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.50 g) was coupled to 4-(2-oxoperhydropyrimidine-1-yl)piperidine (0.225 g) by a method similar to that described in Example 8. The reaction product was not purified by chromatography but converted to the corresponding hydrochloride salt as described in the Example 8 to afford the title compound (0.567 g); mp 160°-170° C. (d); MS: m/z=573(M+1); NMR(CD3 SOCD3): 1.38 (m,6), 1.83 (broad,5), 3.29 (s,3), 4.82 (m,1), 6.74-6.97 (m,2), 7.18-7.64 (m,4). Analysis for C30H38Cl2N4 O3.1.0 HCl.1.5 H2O: Calculated: C, 56.56; H, 6.64, N, 8.79; Found: C, 56.49; H, 6.40; N, 8.78.

Provenance & Evidence