HCID 21839776, compound → HCID 21839783, compound

HRID 725089Notes

Reaction equation

HRID 725089 reaction equation
ClC1C=C(C(C2(C)C3C(=CC=[C:19]([O:22]C)C=3)C(=O)N2)CC=C)C=CC=1Cl.Cl.[Cl:27][C:28]1[CH:29]=[C:30]([CH:35]([CH:51]2[C:59]3[C:54](=[CH:55][CH:56]=[C:57]([O:60][CH:61]([CH3:63])[CH3:62])[CH:58]=3)[C:53](=[O:64])[N:52]2[CH3:65])[CH2:36]CN2CCC(N3CCCNC3=O)CC2)[CH:31]=[CH:32][C:33]=1[Cl:34]>>[Cl:27][C:28]1[CH:29]=[C:30]([CH:35]([CH:51]2[C:59]3[C:54](=[CH:55][CH:56]=[C:57]([O:60][CH:61]([CH3:63])[CH3:62])[CH:58]=3)[C:53](=[O:64])[N:52]2[CH3:65])[CH2:36][CH:19]=[O:22])[CH:31]=[CH:32][C:33]=1[Cl:34]

Participants

3

Reactant 2

HCID 21839776HCID 21839776, compoundHCID 21839922HCID 21839922, compound

Product 1

HCID 21839783HCID 21839783, compound

Procedure

The intermediate 3-(3,4-dichlorophenyl)-3-(6-isopropoxy-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde was prepared from 3-[1-(3,4-dichlorophenyl)but-3-enyl]-5-methoxy-3-methyl-2,3-dihydro-1H-isoindol-1-one (described at Example 30 sub-part c.) by treating the ether as described in Example 31 sub-part a. to give the corresponding alcohol, followed by a sequence similar to that described in Example 42 sub-parts a.-b.

Sources & evidence

ORD record
ord-5c7c31678b714815b45c84e48e238e0e
Source dataset
uspto-grants-1998_01
Patent number
US05705505

Reaction notes

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