4-(2-(Methylsulfinyl)phenyl)piperidine → (3R)-3-[(1S)-1-(3,4-Dichlorophenyl)-3-(4-(2-methylsulfinylphenyl)piperidino)propyl]-2-ethyl-2,3-dihydro-isoindol-1-one hydrochloride

Participants

Reaction Steps

(3S)-3-(3,4-Dichlorophenyl)-3-[(1R)-2-ethyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl]propionaldehyde (0.4 g) was coupled to 4-(2-methylsulfinylphenyl)piperidine (0.36 g) using a method similar to that described in Example 1, to afford the title compound (0.25 g); mp 120°-125° C. (d); MS: m/z=569(M+1); NMR (CDCl3): 1.20 (m,3), 2.69 (s,3), 4.88 (m,1), 6.59-7.9 (m,11). Analysis for C31 H34Cl2N2O2S.HCl.1.5 H2O: Calculated: C, 58.82; H, 6.05, N, 4.43; Found: C, 58.51; H, 6.07; N, 4.59.

Provenance & Evidence