Toluene → HCID 67653950, compound

Participants

Reaction Steps

4.6 g (40 mmol) of thionyl chloride dissolved in 12 ml of anhydrous toluene were dropwise added to a suspension of 9.0 g (20 mmol) of 6-{N-[2,5-di(benzyloxy)benzoyl]amino}hexanoic acid (compound of Example 3) in 60 ml of anhydrous toluene and 0.93 g (13 mmol) of anhydrous dimethylformamide at room temperature during 5 minutes stirring. The reaction mixture was stirred at 50° C. for 1 hour then evaporated under reduced pressure to dryness at a temperature below 50° C. The residue obtained was thoroughly triturated with ether, filtered to obtain 7.68 g (82%) of the aimed product, m.p.: 90°-94° C.

Provenance & Evidence