HCID 57085301, compound → HCID 57236480, compound

Participants

Reaction Steps

In 5 ml of 4N-hydrogen chloride/dioxane solution was dissolved 0.42 g of (2S)-N-(2-nitrooxyethyl)-2-acetylamino-3-(tetrahydropyran-2-yl)oxypropanamide, and the resulting solution was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and the residue was neutralized with aqueous sodium hydrogencarbonate. The mixture was extracted with ethyl acetate, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography through silica gel using ethyl acetate as an eluent and recrystallized from ethyl acetate to give 48 mg of the title compound as colorless crystals.

Provenance & Evidence