HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinamido)cyclopropyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride | HCID 66824369 | — |
| Reactant | 2-(3-(3-Chlorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid | HCID 67958317 | — |
| Product | Methyl 4-(1-(2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinamido)cyclopropyl)benzoate | HCID 67958389 | 11.2% |
Reaction Steps
The title compound (D175) (14 mg) was prepared according to the experimental procedure described in Description 144 starting from 2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D124) (85 mg, 0.228 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (51.92 mg, 0.228 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-59f9eb84b33e4e7bbf30746e0729fbfe |
| Source note | uspto-grants-2014_09 |