HRID72518

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66824369

未命名化合物

结构：O=C(O)c1cc(C(F)(F)F)cnc1N1CC(Oc2ccc(F)c(C(F)(F)F)c2)C1

HCID86697875

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(C2(NC(=O)c3cc(C(F)(F)F)cnc3N3CC(Oc4ccc(F)c(C(F)(F)F)c4)C3)CC2)cc1

HCID86697879

未命名化合物

收率 34.3%

PROCEDURE

实验过程

The title compound (D176) (52 mg) was prepared according to the experimental procedure described in Description 144 starting from 2-(3-(4-fluoro-3-(trifluoromethyl)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D125) (108 mg, 0.254 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (57.95 mg, 0.254 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-77534bf9cad0429eb72b5664eb5559b5
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08828987B2
来源说明: uspto-grants-2014_09

反应 SMILES

[F:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11]3[N:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:12]=3[C:13](O)=[O:14])[CH2:8]2)=[CH:4][C:3]=1[C:26]([F:29])([F:28])[F:27].Cl.[NH2:31][C:32]1([C:35]2[CH:44]=[CH:43][C:38]([C:39]([O:41][CH3:42])=[O:40])=[CH:37][CH:36]=2)[CH2:34][CH2:33]1>>[F:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11]3[N:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:12]=3[C:13]([NH:31][C:32]3([C:35]4[CH:44]=[CH:43][C:38]([C:39]([O:41][CH3:42])=[O:40])=[CH:37][CH:36]=4)[CH2:34][CH2:33]3)=[O:14])[CH2:8]2)=[CH:4][C:3]=1[C:26]([F:28])([F:27])[F:29]