1,4-Dioxane → HCID 86751848, compound

Participants

Reaction Steps

To a solution of 2.90 g of (1R,3aS,5S,7aR)-1-[(E)-3-hydroxy-1-propenyl]-5-(4-tert-butyldimethyl-silyloxyphenyl)-7a-methylperhydroinden-3a-ol in 40 ml of dioxane, 13.80 g of MnO2 were added while cooling in an ice bath. The mixture was stirred at room temperature for 1 hr, filtered through celite and the filtrate was made acid to pH 1 with 3N HCl and, using the same procedure described in Prepn, 1, the title compound (II-bb) (2.75 g) was obtained as a white solid.

Provenance & Evidence