Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinamido)cyclopropyl)benzoate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride	HCID 66824369	—
Edukt	2-(3-(3-(Trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid	HCID 86697876	—
Produkt	Methyl 4-(1-(2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinamido)cyclopropyl)benzoate	HCID 86697880	73%

Reaktionsschritte

The title compound (D177) (113 mg) was prepared according to the experimental procedure described in Description 144 starting from 2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D126) (110 mg, 0.26 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (59.31 mg, 0.26 mmol).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08828987B2
Quelldatensatz	uspto-grants-2014_09
ORD ID	ord-80562b2dd73a400fba157f05a2862491
Quellennotiz	uspto-grants-2014_09