HCID 21458444, compound → HCID 21458453, compound

HRID 725203Notes

Reaction equation

HRID 725203 reaction equation
C([N:8]1[CH2:19][CH2:18][N:17](CC2C=CC=CC=2)[CH2:16][CH2:15][N:14](CC2C=CC=CC=2)[CH2:13][CH2:12][N:11]([CH2:34][C:35](=[O:82])[NH:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][O:42][CH2:43][CH2:44][NH:45][C:46](=[O:81])[CH2:47][N:48]2[CH2:59][CH2:58][N:57](CC3C=CC=CC=3)[CH2:56][CH2:55][N:54](CC3C=CC=CC=3)[CH2:53][CH2:52][N:51](CC3C=CC=CC=3)[CH2:50][CH2:49]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[N:11]1([CH2:34][C:35](=[O:82])[NH:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][O:42][CH2:43][CH2:44][NH:45][C:46](=[O:81])[CH2:47][N:48]2[CH2:59][CH2:58][NH:57][CH2:56][CH2:55][NH:54][CH2:53][CH2:52][NH:51][CH2:50][CH2:49]2)[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 21458444HCID 21458444, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21458453HCID 21458453, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A 100 mL Autoclave pressure reactor was charged with 9.2 g (8.3 mmol) of 8, 50 mL of ethanol and 3 g of 10% Pd/C. The reactor was pressurized to 220 psig with hydrogen for 3 hours at 80° C. The mixture was filtered and the filtrate was concentrated to a slightly yellow oil. 1H NMR, 13C NMR, and mass spectroscopy data were consistent with 9. The yield of 9 was essentially quantitative.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated to a slightly yellow oil

Sources & evidence

ORD record
ord-f5175069896246cbab542c66fdb8935d
Source dataset
uspto-grants-1998_01
Patent number
US05705637

Reaction notes

Loading…