Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(2-(3-(3,4-difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinamido)cyclopropyl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride | HCID 66824369 | — |
| 반응물 | 2-(3-(3,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid | HCID 67958244 | — |
| 생성물 | Methyl 4-(1-(2-(3-(3,4-difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinamido)cyclopropyl)benzoate | HCID 67958495 | 54.7% |
반응 단계
The title compound (D179) (80 mg) was prepared according to the experimental procedure described in Description 144 starting from 2-(3-(3,4-difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D128) (100 mg, 0.267 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (60.83 mg, 0.267 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828987B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-44201a5a0e804396bed9aec492e2a6ab |
| 출처 메모 | uspto-grants-2014_09 |