HRID72524

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66824369

未命名化合物

结构：COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CC(Nc4ccc(F)cc4F)C3)CC2)cc1

HCID67958748

未命名化合物

结构：O=C(O)c1cc(C(F)(F)F)cnc1N1CC(Oc2ncc(F)cn2)C1

HCID67958881

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(C2(NC(=O)c3cc(C(F)(F)F)cnc3N3CC(Oc4ncc(F)cn4)C3)CC2)cc1

HCID67958127

未命名化合物

PROCEDURE

实验过程

The title compound (D182) (36 mg) was prepared according to the experimental procedure described in Description (D169) starting from 2-(3-((5-fluoropyrimidin-2-yl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D131) (42 mg, 0.117 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (27 mg, 0.117 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6dd91fbf0bcd473a97384028a2e713ba
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08828987B2
来源说明: uspto-grants-2014_09

反应 SMILES

ClC1C=NC(N2CC(NC3C=CC(F)=CC=3F)C2)=C(C=1)C([NH:9][C:10]1([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH2:12][CH2:11]1)=O.[F:37][C:38]1[CH:39]=[N:40][C:41]([O:44][CH:45]2[CH2:48][N:47]([C:49]3[N:57]=[CH:56][C:55]([C:58]([F:61])([F:60])[F:59])=[CH:54][C:50]=3[C:51]([OH:53])=O)[CH2:46]2)=[N:42][CH:43]=1.Cl.NC1(C2C=CC(C(OC)=O)=CC=2)CC1>>[F:37][C:38]1[CH:43]=[N:42][C:41]([O:44][CH:45]2[CH2:48][N:47]([C:49]3[N:57]=[CH:56][C:55]([C:58]([F:61])([F:60])[F:59])=[CH:54][C:50]=3[C:51]([NH:9][C:10]3([C:13]4[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=4)[CH2:12][CH2:11]3)=[O:53])[CH2:46]2)=[N:40][CH:39]=1