Sodium Hydroxide → HCID 131720379, compound

Temperature

110 °C

973 g (6.4 mol) of propanephosphonic acid dimethyl ester are heated to 90° C. and 1280 g (6.4 mol) of 20% strength sodium hydroxide solution are added dropwise, while stirring vigorously. During this procedure, the temperature is increased slowly to 110° C., and at the same time 238 g of a methanol/water mixture distill off over a Vigreux column. The resulting solution is evaporated in vacuo and the residue which remains is dried in a vacuum drying cabinet. 1020 g of propanephosphonic acid monomethyl ester sodium salt are obtained with a purity of 92%, according to 31-P-NMR. This corresponds to a yield of about 100%.

1. distillationat the same time 238 g of a methanol/water mixture distill off over a Vigreux column
2. customThe resulting solution is evaporated in vacuo
3. customthe residue which remains is dried in a vacuum
4. customdrying cabinet

ORD record

ord-c05f3d9d68e54b4ea3ced816c7e255e8

Source dataset

uspto-grants-1998_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05705670