HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-21-hydroxymethyl-21-methyl-5beta-pregn-20-ene-3beta,14beta-diol → (E)-3beta,14beta-dihydroxy-21-methyl-5beta-pregn-20-ene-21-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-21-hydroxymethyl-21-methyl-5beta-pregn-20-ene-3beta,14beta-diol | HCID 10690052 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (E)-3beta,14beta-dihydroxy-21-methyl-5beta-pregn-20-ene-21-carboxaldehyde | HCID 10666253 | 89.8% |
Reaction Steps
To a solution of 8.40 g of (E)-21-hydroxymethyl-21-methyl-5β-pregn-20-ene-3β,14β-diol in 200 ml of chloroform, 84.0 g of MnO2 were added at room temperature. The mixture was stirred overnight and then filtered through Celite. The organic solution was evaporated to dryness to give 7.50 g of the title compound (II-a) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05705662 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-2fe86dca213940f09a6c3bf12be6d161 |
| Source note | uspto-grants-1998_01 |