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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 72528Generated: October 25, 2026

Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(5-fluoro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

https://huagongshe.com/reaction/72528

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 66824369—
Reactant5-Fluoro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinic acidHCID 67958470—
ProductMethyl 4-(1-(5-fluoro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoateHCID 6795833799.3%

Reaction Steps

The title compound (D189) (39 mg) was prepared according to the experimental procedure described in Description 169 starting from 5-fluoro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinic acid (D134) (27 mg, 0.072 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (16.5 mg, 0.072 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08828987B2
Source datasetuspto-grants-2014_09
ORD IDord-04a82af96635471eb72faf2e17cf455b
Source noteuspto-grants-2014_09